Table 1 VAM biomarker values in three different tumor areas and peritumoral edema.

	Ex.	Tumor response	Tumor non-resp.	Tumor progress	Edema response	Edema non-resp.	Edema progress	cNAB
	Ex.	(N = 13)^a	(N = 9)^a	(N = 8)^a	(N = 13)^a	(N = 9)^a	(N = 8)^a	(N = 13)^a
MTI	bl	−82.2 ± 60.4	−147.8 ± 80.2	−6.0 ± 5.8	0.3 ± 1.0	−0.4 ± 1.1	−0.5 ± 1.2	0.0 ± 0.7
[s^−5/2]	fu	−4.2 ± 6.4*	−196.0 ± 78.7*	−67.1 ± 66.1*	−1.4 ± 2.7	−0.1 ± 2.6	0.4 ± 2.9	0.2 ± 0.6
N_U	bl	498 ± 132	484 ± 171	277 ± 125	101 ± 52	120 ± 43	151 ± 53	180 ± 37
[mm⁻²]	fu	212 ± 103*	656 ± 101*	511 ± 170*	173 ± 94*	162 ± 43*	129 ± 48	164 ± 28
R_U	bl	102 ± 45	86 ± 48	42 ± 19	83 ± 44	61 ± 18	43 ± 19	29 ± 7
[µm]	fu	65 ± 36*	124 ± 39*	84 ± 53*	54 ± 27	77 ± 33	91 ± 28*	28 ± 6
Curv	bl	−7 ± 6	−8 ± 11	−22 ± 22	−197 ± 97	−140 ± 55	−33 ± 24	−15 ± 6
	fu	−85 ± 103*	−30 ± 79	−11 ± 13	−49 ± 7*	−118 ± 82	−179 ± 76*	−17 ± 8

Values are mean values ± standard deviation.
^aIn parentheses: number of patients.
*Values marked with an asterisks are significant (P < 0.05) different to the value at the baseline examination.
Note: MTI = microvessel type indicator; N_U = microvessel density; R_U = microvessel radius; Curv = curvature of the long-axis of the VHL; Exam. = examination; bl = baseline; fu = 3-month follow-up, cNAB = contralateral normal appearing brain.

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