Figure 4 | Scientific Reports

Figure 4

From: Growth differentiation factor 15 promotes blood vessel growth by stimulating cell cycle progression in repair of critical-sized calvarial defect

Figure 4

GDF15-induced capillary-like tube formation on Matrigel in vitro. At 12 h, the capillary tube branch points formed in 50 ng/ml and 100 ng/ml groups demonstrated higher than that in the control (A1–D1). There is no difference between 50 ng/ml and 100 ng/ml groups (E). At 24 h, HUVECs were treated with 25 ng/ml, the tube formation of which is lower than that in 50 ng/ml and 100 ng/ml groups (A2–D2,E). At 48 h, tube branch points in the experimental groups were higher than in the control group, and we didn’t observe the difference among the three experimental groups (B3–D3,E).

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