Figure 2 | Scientific Reports

Figure 2

From: Intravoxel incoherent motion diffusion-weighted imaging for discriminating the pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Figure 2

A LARC patient from the non-pCR and PR groups (TRG 2). Images in row A and B are T2WI, IVIM-DWI parametric and pathological maps before and after nCRT, respectively. The ADC, D, D* and f values before nCRT were 1.1 × 10−3 mm2/s, 0.925 × 10−3 mm2/s, 40.3 × 10−3 mm2/s and 0.165, respectively. The ADC, D, D*, and f values after nCRT were 1.69 × 10−3 mm2/s, 1.61 × 10−3 mm2/s, 37.1 × 10−3 mm2/s and 0.118, respectively. The pathology map (haematoxylin-eosin staining, original magnification x40) after nCRT indicates an increased number of residual cancer cells with predominating fibrosis (TRG 2). LARC, locally advanced rectal cancer; non-pCR, non-pathological complete response; PR, poor response; TRG, tumour regression grade; T2WI, T2-weighted imaging; IVIM-DWI, intravoxel incoherent motion diffusion-weighted imaging; nCRT, neoadjuvant chemoradiotherapy; ADC, apparent diffusion coefficient; D, pure diffusion coefficient; D*, pseudo-diffusion coefficient; f, perfusion fraction.

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