Table 4 Diagnostic efficacy of the IVIM-DWI parametric values in the differentiation between the pCR and non-pCR groups.

From: Intravoxel incoherent motion diffusion-weighted imaging for discriminating the pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Parameter

AUC (95% CI)

Cut-off value

Sensitivity

Specificity

PPV

NPV

P

preD*

0.744(0.574–0.913)

72.20 × 10−3 mm2/s

60.0%

84.4%

54.5%

87.1%

0.804a, 0.674b

pref

0.713(0.529–0.896)

0.20

80.0%

71.9%

47.1%

92.0%

0.977c, 0.069d

postD

0.797(0.626–0.968)

1.67 × 10−3 mm2/s

60.0%

96.9%

85.7%

88.6%

0.281e, 0.273f

∆%ADC

0.716(0.556–0.875)

47.6%

80.0%

65.6%

42.1%

91.3%

0.009g#, 0.801h

∆%D

0.881(0.776–0.986)

65.8%

90.0%

75.0%

52.9%

95.9%

0.125i, 0.394j

  1. #Significance before multiple comparison correction, but not significant after correction; IVIM-DWI, intravoxel incoherent motion diffusion-weighted imaging; pCR, pathological complete response; non-pCR, non-pathological complete response; ADC, apparent diffusion coefficient; D, pure diffusion coefficient; D*, pseudo-diffusion coefficient; f, perfusion fraction; AUC, area under the curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; apreD* vs pref, bpreD* vs postD, cpref vs ∆%ADC, dpref vs ∆%D, epref vs postD, fpostD vs ∆%D, g∆%ADC vs ∆%D, hpreD* vs ∆%ADC, ipreD* vs ∆%D, jpostD vs ∆%ADC.
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