Table 4 Diagnostic accuracy of different indexes for the prediction of liver fibrosis in HBeAg negative CHB.

	Optimized cutoff	Sensitivity (%)	Specificity (%)	AUROC (95% CI)	LR+	LR−	P value	P value of ROC contrast test*
F0-F1 vs. F2-F4
APRI	0.553	61.18	75.86	0.709 (0.599, 0.820)	2.534	0.512	0.001	0.994
	0.5*	69.41	58.62	—	1.677	0.522	0.007	—
	1.5*	17.65	100.00	—	—	0.824	0.035	—
FIB-4	1.328	74.12	72.41	0.785 (0.698, 0.873)	2.687	0.357	<0.001	0.240
	1.45*	65.88	75.86	—	2.729	0.450	<0.001	—
	3.25*	22.35	100.00	—	—	0.776	0.012	—
NLR	2.321	35.29	86.21	0.477 (0.372, 0.582)	2.559	0.751	0.713	0.002
AAR	0.916	51.76	79.31	0.621 (0.512, 0.729)	2.502	0.608	0.053	0.336
RPR	0.072	76.47	62.07	0.667 (0.549, 0.784)	2.016	0.379	0.008	0.523
GPR	0.413	71.76	65.52	0.709 (0.598, 0.820)	2.081	0.431	0.001	—
F0-F2 vs. F3-F4
APRI	0.657	57.75	72.09	0.671 (0.570, 0.772)	2.505	0.365	0.002	0.053
FIB-4	1.411	71.83	62.79	0.717 (0.620, 0.813)	2.848	0.332	<0.001	0.434
NLR	3.228	14.08	93.02	0.426 (0.321, 0.530)	1.059	0.638	0.185	<0.001
AAR	0.916	49.30	65.12	0.533 (0.423, 0.644)	2.227	0.849	0.551	0.008
RPR	0.075	74.65	58.14	0.658 (0.555, 0.762)	6.895	0.501	0.005	0.065
GPR	0.413	80.28	67.44	0.764 (0.669, 0.859)	2.850	0.219	<0.001	—
F0-F3 vs. F4
APRI	0.724	57.14	68.06	0.658 (0.554, 0.762)	1.789	0.630	0.005	0.314
	1.0*	42.86	77.78	—	1.929	0.735	0.020	—
	2.0*	11.90	98.61	—	8.571	0.893	0.047	—
FIB-4	1.626	71.43	62.50	0.716 (0.621, 0.812)	1.905	0.457	<0.001	0.858
NLR	2.370	33.33	75.00	0.494 (0.380, 0.607)	1.333	0.889	0.911	0.011
AAR	0.700	76.19	43.06	0.549 (0.443, 0.655)	1.338	0.553	0.381	0.053
RPR	0.072	85.71	45.83	0.669 (0.566, 0.771)	1.582	0.312	0.003	0.487
GPR	0.693	59.52	77.78	0.706 (0.606, 0.807)	2.679	0.520	<0.001	—

*Compared with GPR.
AUROC, area under the receiver operating characteristic curve; CI, confidence interval; LR−, negative likelihood ratio; LR+, positive likelihood ratio; AAR, aspartate aminotransferase/alanine aminotransferase ratio; APRI, aspartate aminotransferase-to-platelet ratio index; FIB-4, fibrosis index based on the four factors; GPR, gamma-glutamyl transpeptidase to platelet ratio; NLR, neutrophil-to-lymphocyte ratio; RPR, red cell distribution width-to-platelet ratio. *Threshold recommended by the WHO¹².

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