Figure 1
From: Periostin-binding DNA aptamer treatment attenuates renal fibrosis under diabetic conditions
Periostin, fibronectin, and type I collagen expression in inner medullary collecting duct (IMCD) cells treated with or without TGF-β1. (A) Periostin, fibronectin, and type I collagen mRNA levels (n = 6). Compared to control IMCD cells, periostin, fibronectin, and type I collagen mRNA expression were significantly increased in TGF-β1-treated cells (10 ng/ml). (B) A representative western blot analysis of periostin, fibronectin, and type I collagen protein (a representative of 4 blots). The protein expression of periostin, fibronectin, and type I collagen were increased significantly in IMCD cells exposed to TGF-β1. Uncropped scans are presented in Supplementary Figure 2. C, control. *P < 0.05 vs. C.
