Figure 3 | Scientific Reports

Figure 3

From: Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression

Figure 3

Hypoxia treatment induced epithelial to mesenchymal transition (EMT) phenotype in ovarian cancer cells. (A) Transwell assay was used to detect the invasion of ovarian cancer cell line HO8910. Data of three replicates are shown as means (±SD). ***P < 0.001. (B–G) RT-PCR was performed to detect the expression of Vimentin, E-cadherin and Snail in ovarian cancer cells SKOV3 and HO8910 after 12 h and 24 h of hypoxia treatment, GAPDH was used as an internal reference. *p < 0.05, **p < 0.01, ***p < 0.001.

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