Figure 3

The scatter plots of seven typical ligand-receptor pairs demonstrated the altered correlations between five cancer (orange dots) and their corresponding normal tissues (blue dots). We showed the Spearman correlations of the gene expressions of ligand-receptor pairs in both normal and cancer sample for five cancer types. The ligand-receptor pairs were grouped into 3 categories: 1) gaining the correlation in cancer tissues (first 3 rows); 2) losing the positive correlation in cancer tissues (4^th ad 5^th row); 3) lose the negative correlations in cancer tissues (6^th and 7^th row). Each dot represent one ligand-receptor gene expression in one sample. The line is a regression line to visualize the trend of the data.