Figure 5
From: Integrated analysis of mRNA and miRNA expression in HeLa cells expressing low levels of Nucleolin
NCL expression affects fatty acids synthesis and accumulation. (A) Network of the genes involved in fatty acids biosynthesis, beta-oxidation or degradation that are significantly deregulated in nucleolin depleted cells. In red genes that are down-regulated (FC > 1.5), pink (1.3 < FC > 1.5) and in green genes that are upregulated. (B) Fatty acids analysis. Samples from siRNA control (siCTL) and siRNA nucleolin (siNCL) were processed as indicated in the materials and methods. Highlighted in red the fatty acids that are down regulated and in green the fatty acids that accumulate in NCL depleted cells. The data are presented for each fatty acids as a percentage compared to the total fatty acids. The amount of fatty acids in NCL depleted cells is higher (45.5) compared to control cells (28.9).
