Figure 6
From: MicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway
MiR-449c-5p inhibits aortic valve calcification in vivo. (a) The velocity profile in the aortic annulus measured by echocardiography six weeks after transfection in vitamin D3-treated mice. (b) Quantitative analysis of the velocity in the aortic annulus in each group. (c) Quantitative analysis of transvalvular gradients in each group. (d) qRT-PCR analysis of miR-449c-5p expression in the aortic valves of mice at day 5. (e) qRT-PCR analysis of Smad4 expression level in the aortic valves of mice at day 10. n = 7 in each group. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01.
