Figure 6

Degradation of hydroxybenzenes and hydroxybenzoates in the yeasts C. parapsilosis and C. albicans. The two Candida species differ in biochemical pathways involved in degradation of hydroxyaromatic substrates as well as in the transport systems for these compounds. While C. parapsilosis assimilates both hydroxybenzenes and hydroxybenzoates, C. albicans utilizes a wider range of hydroxybenzenes, but not hydroxybenzoates. Although the HHQ variant of the 3-oxoadipate pathway operates in both species, C. albicans lacks decarboxylating monooxygenase Mnx1 and hydroxybenzoate transporter Hbt2, which are present in C. parapsilosis. Mnx1 and Hbt2 are paralogous to Mnx2 and Hbt1, respectively, that are involved in the gentisate pathway. Note that C. parapsilosis proteins Mnx3 and Hdx1 are orthologous to C. albicans proteins Phh1/Phh2 and Hqd1, respectively.