Figure 3 | Scientific Reports

Figure 3

From: A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma

Figure 3

Antitumour effect of c4G12 in a dog with oral malignant melanoma. A dog with oral malignant melanoma was treated with 2 mg/kg (weeks 0–24) or 5 mg/kg (weeks 24–44) c4G12 every 2 weeks and the tumour burden was evaluated by gross examination and computed tomography (CT). (a,d) Tumour appearance at baseline (week 0). (b,e) Tumour appearance after 10 weeks of c4G12 treatment (c,f) Tumour appearance after 34 weeks of c4G12 treatment. Contrast-enhanced, and matched transverse CT images were shown. Arrowheads indicate the tumour lesions. (g) Changes in tumour burden. The longest diameter of target lesion was measured and recorded every 2 weeks. Reduction in tumour diameter by >30% (time points indicated by open circles) was considered PR (partial response; see Methods for definition of response).

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