Figure 5
From: Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats
Serelaxin decreased kidney lipid accumulation. (a) Representative images of oil red O staining (20 X), which staining for neutral lipids, showed that increased neutral lipid accumulation in kidney of DOCA-salt rats was prevented by the treatment with serelaxin. The expression of fatty acid, triglyceride and cholesterol metabolism related genes were determined by quantitative real-time PCR (qRT-PCR) analysis, (b) SREBP-1c, (c) ChREBP, (d) FATP1, (e) Acox1, (f) SREBP-2, (g) HMGCR, (h) LDLR, (i) ABCA1. (j) Serelaxin regulated the genes involved in fatty acid, triglyceride, and cholesterol metabolism in DOCA-salt rats. Results are expressed as means ± SEM. Statistical analysis was performed with one-way ANOVA.
