Figure 3

High-scoring protein interactome maps for differentially expressed proteins in the OB during AD progression. Visual representation of the relationships between differential expressed proteins and functional interactors in initial (a), intermediate (b), and advanced AD stages (c). Dysregulated proteins are highlighted in red (up-regulated) and green (down-regulated) for each stage. Continuous and discontinuous lines represent direct and indirect interactions respectively. The complete legend including main features, molecule shapes, and relationships is found in http://ingenuity.force.com/ipa/articles/Feature_Description/Legend.