Table 2 Estimates of current malaria infection and exposure.

From: Naturally acquired antibody response to Plasmodium falciparum describes heterogeneity in transmission on islands in Lake Victoria

Category

Characteristic

Study site

Ungoye

Mfangano

Takawiri

Kibuogi

Ngodhe

Sample size

Number of sample for microscopy

1238

1938

883

336

633

Number of sample for PCR

1237

1938

883

336

632

Number of sample for ELISA

868

1574

770

325

575

Blood smear microscopy

Positive for Plasmodium spp., n (%)

403 (32.6)

393 (20.3)

38 (4.3)

21 (6.3)

39 (6.2)

Geometric mean parasite density, parasite/µl (95% CI)

1101 (942–1286)

1045 (877–1245)

1458 (841–2526)

1665 (641–4326)

1229 (657–2298)

P. falciparum parasite rate in children 2–10 years1, n/N2 (%)

263/669 (39.3)

211/846 (24.9)

24/419 (5.7)

11/146 (7.5)

25/234 (10.7)

P. falciparum gametocytes rate, n/N3 (%)

41/397 (10.3)

34/358 (9.5)

2/36 (5.6)

5/21 (23.8)

3/39 (7.7)

PCR

Positive for Plasmodium spp., n (%)

1048 (84.7)

1033 (53.3)

153 (17.3)

60 (17.9)

82 (13.0)

P. falciparum parasite rate in children 2–10 years, n/N2 (%)

433/669 (64.7)

366/847 (43.2)

62/420 (14.8)

26/146 (17.8)

35/234 (15.0)

ELISA

Median AMA-1 OD (IQR)

0.89 (0.48–1.08)

0.79 (0.33–1.06)

0.35 (0.09–0.82)

0.48 (0.14–0.92)

0.40 (0.13–0.83)

Median AMA-1 antibody titre (IQR)

1579 (358–5564)

1001 (189–4083)

194 (40–1082)

295 (44–1418)

225 (47–1025)

AMA-1 SCR, (95% CI)

0.204 (0.181–0.228)

0.166 (0.153–0.181)

0.139 (0.123–0.156)

0.136 (0.113–0.165)

0.122 (0.106–0.141)

AMA-1 estimate EIR4 (95% CI)

12.1 (8.9–16.2)

7.1 (5.7–8.9)

4.4 (3.2–6.0)

4.2 (2.6–7.0)

3.2 (2.2–4.6)

Median MSP-119 OD (IQR)

0.30 (0.13–0.81)

0.33 (0.17–0.79)

0.19 (0.11–0.43)

0.20 (0.12–0.51)

0.18 (0.11–0.43)

Median MSP-119 antibody titre (IQR)

96 (33–580)

118 (45–530)

43 (24–162)

52 (28–217)

41 (22–131)

MSP-119 SCR, (95% CI)

0.079 (0.070–0.089)

0.075 (0.069–0.082)

0.043 (0.037–0.049)

0.048 (0.039–0.060)

0.046 (0.039–0.054)

MSP-119 estimate EIR4 (95% CI)

7.1 (5.5–9.2)

6.4 (5.4–7.7)

2.0 (1.4–2.6)

2.5 (1.6–4.0)

2.3 (1.6–3.2)

Median CSP OD (IQR)

0.40 (0.22–0.68)

0.41 (0.26–0.72)

0.24 (0.12–0.41)

0.29 (0.20–0.44)

0.24 (0.14–0.40)

Median CSP antibody titre (IQR)

385 (207–834)

446 (246–946)

221 (106–406)

245 (153–433)

219 (123–422)

CSP SCR, (95% CI)

0.008 (0.006–0.010)

0.011 (0.010–0.013)

0.008 (0.006–0.010)

0.010 (0.007–0.014)

0.009 (0.007–0.011)

  1. 1Total of two children has no data on microscopy. 2Total numbers of children 2–10 years old tested. 3Total P. falciparum positive by slide microscopy. 4EIR was estimated from the SCR data using a previously described relationship10. OD, optical density; CI, confidence interval; IQR, interquartile range (25th–75th percentile); SCR, seroconversion rate.
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