Table 1 Characteristics of the two groups of patients at study enrollment (R: responsive; NR: not responsive to therapy).

no patients

21

12 (57%)

9 (43%)

Sex (Male) [no (%)]

16 (76%)

8 (67%)

8 (89%)

Weight (kg)

85 (73.75, 90.5)

82.5 (72.5, 90.5)

85 (76.75, 94)

BMI - Body Mass Index

26.85 (24.975, 30.335)

26.54 (23.505, 30.630)

27.76 (25.46, 30.407)

Age (years)

69.649 (63.366, 80.26)

66.503 (60.622, 74.784)

74.918 (66.198, 81.886)

No Affected Organs

4 (3, 5)

4 (3.5, 5)

4 (3, 5)

Lactate (mmol/L)

4 (2.95, 5.6)

4.25 (3, 5.6)

3.6 (2.7, 5.275)

Systolic Arterial Pressure (mmHg)

85 (74.5, 91.25)

87.5 (74, 91.5)

85 (80.25, 91.25)

Diastolic Arterial Pressure (mmHg)

47 (44.5, 49.5)

46.5 (42.5, 47)

49 (46.5, 51.25)

Mean Arterial Pressure (mmHg)

60 (56.25, 62.25)

58.5 (54, 61.5)

62 (58.5, 63.25)

Heart Rate (bpm)

111 (91.5, 125.5)

110 (89.5, 122)

111 (98, 134)

Respiratory Rate (breath per minute)

20 (19, 25.5)

20.5 (18, 25.5)

20 (19.75, 26.25)

GCS

3 (3, 5.25)

3 (3, 4.5)

3 (3, 6)

SAS

2 (1, 2.25)

2 (1, 2.5)

1 (1, 2.25)

SOFA

14 (12, 15.25)

14 (13, 15.5)

13 (10.75, 15.25)

APACHE-II

34 (29.75, 38)

35 (31, 37.5)

31 (28.5, 41)

Temperature (°C)

37.5 (36.75, 38.05)

37.45 (36.7, 37.9)

37.5 (36.975, 38.6)

Urine Output (mL/day)

1550 (803.75, 1945)

1778.5 (1135, 1975)

805 (417.5, 1741.25)

Hematocrit (%)

35 (30.65, 38)

35.05 (31.8, 36.85)

35 (29.95, 41.75)

White Blood Cells (10³/mm³)

11.7 (9.75, 19.675)

14.3 (10.15, 27.55)

10.5 (9.2, 12.6)

Creatinine (mg/dL)

1.7 (1.175, 2.025)

1.65 (1.3, 2.05)

1.7 (1.075, 2.075)

Na (mmol/L)

140 (135, 140.25)

140 (136.5, 144.5)

139 (133, 140)

K (mmol/L)

4.2 (3.9, 4.725)

4.2 (3.55, 4.85)

4.3 (4.15, 4.725)

Platelets (10³/mm³)

168 (95.5, 198)

153 (90, 197)

194 (94.5, 202.25)

Biliuribine (mg/dL)

1.3 (0.95, 2.05)

1.44 (1.025, 1.95)

1.3 (0.775, 3.7)

Glycemia (mg/dL)

167 (124.25, 196.5)

160 (120.5, 178)

185 (119.5, 212.5)

Prothrombin Time INR

1.3 (1.1, 1.5)

1.4 (1.15, 1.55)

1.2 (1.1, 1.325)

Chloride (mEq/L)

106 (101.25, 109.25)

108.5 (103.5, 113)

103 (97, 106)

aPPT - activated Partial Thromboplastin Time

46.3 (42.525, 58.175)

47.3 (42.25, 60.2)

46.1 (42.9, 56.85)

Prothrombin Time (seconds)

62 (49.25, 81.25)

59 (41.5, 76)

62 (56.5, 86)

Fibrinogen (mg/dL)

4.7 (3.95, 6.625)

4.8 (4.6, 6.25)

4.5 (2.275, 7.325)

C-Reactive Protein (mg/L)

273.4 (155.4, 352.05)

274.65 (173.9, 342.7)

188 (98.35, 405.35)

pH

7.31 (7.235, 7.345)

7.285 (7.245, 7.335)

7.33 (7.21, 7.36)

PaO₂ (mmHg)

88 (77.5, 109)

90 (77.5, 112.5)

83 (75.5, 106.5)

PaCo₂ (mmHg)

38 (35.75, 49)

38 (34.5, 40)

48 (37.25, 49.5)

HCO₃ (mmol/L)

19 (17.75, 20.25)

18 (16.5, 20.5)

19 (18.75, 21.75)

Base excess (mmol/L)

−7.2 (−9.775, −4.225)

−8.05 (−10.05, −4.85)

−6.2 (−8.5, −2.1)

FiO₂

0.5 (0.438, 0.663)

0.55 (0.45, 0.675)

0.5 (0.37, 0.637)

PaO₂/FiO₂

172.31 (128.49, 255.5)

167.265 (130.475, 3.215)

240 (126.42, 288.035)

O₂ Saturation (%)

96 (95, 98)

96.5 (95.5, 98)

95 (93, 97.25)

Saturation O₂/FiO₂

190 (146.207, 221.248)

176.665 (143.185, 13.33)

200 (144.753, 270.358)