Figure 1
From: AhR-deficiency as a cause of demyelinating disease and inflammation
AhR knockout mice as a model of INS pathologies. (A) Raw traces of spontaneous eye movements recorded in the presence of light (8 week-old AhR-KO). (B) Nystagmus amplitude (degrees) and frequency (Hz) recorded at P26 and P40 (n = 8). (C) Example of whole brain staining of a WT and an AhR KO mouse: Optic Nerve (ON), Optic Chiasm (OC), Optic Tract (OT), Thalamus (Th) and Superior Colliculus (SC). (D) Left: Average Visually Evoked Potentials (VEP) traces recorded in WT (black line, n = 9) or AhR KO mice (blue line, n = 8) (100% contrast and 0.05 cpd stimulation). The white line represents the average and the envelope around (blue or black) represents the SEM. Middle: Initiation time of the VEPs measured on both WT (black bar) and AhR KO mice (blue bar). Right: VEP amplitudes with decreasing contrast stimulation or decreasing visual acuity (i.e. increasing spatial frequency). Dotted lines represent the noise. Arrows represent the first stimulation significantly different from the noise. (*p < 0.05; **p < 0.01).
