Table 3 Associations of 9 single nucleotide polymorphisms in 8 age-related macular degeneration susceptibility genes with visual acuity change during 12 months of ranibizumab treatment in the discovery stage.
Gene | SNP | BETA (95% CI) | P | BETA (95% CI)* | P* |
|---|---|---|---|---|---|
ARMS2/HTRA1 | rs10490924 | −0.012 (−0.057–0.034) | 0.62 | −0.013 (−0.058–0.033) | 0.58 |
CFH | rs800292 | −0.007 (−0.061–0.047) | 0.80 | −0.009 (−0.063–0.044) | 0.74 |
rs1410996 | −0.011 (0.064–0.041) | 0.68 | −0.017 (−0.069–0.036) | 0.54 | |
CETP | rs3764261 | −0.004 (−0.066–0.058) | 0.89 | 0.004 (−0.058–0.065) | 0.90 |
C2/CFB | rs547154 | −0.080 (−0.198–0.039) | 0.19 | −0.094 (−0.213–0.025) | 0.12 |
CFI | rs4698775 | −0.033 (−0.090–0.024) | 0.25 | −0.039 (−0.095–0.018) | 0.18 |
TGFBR1 | rs334353 | 0.029 (−0.018–0.076) | 0.23 | 0.024 (−0.023–0.071) | 0.33 |
APOE | rs4420638 | −0.050 (−0.141–0.040) | 0.25 | −0.045 (−0.135–0.044) | 0.25 |
VEGFA | rs943080 | 0.062 (0.009–0.114) | 0.022 | 0.058 (0.006–0.110) | 0.031 |
