Figure 6
Gene expression of Axin2, Lef1 and DKK1 and Sost was measured at 3, 8, and 24 hours after a single loading session in the left loaded and right nonloaded tibia of 10 and 26 week old female Sost KO and LC mice. Note: Sost expression was only measured in LC mice. (A) Fold changes in gene expression for Sost KO normalized to LC mice. Asterisk indicates a significant difference between Sost KO compared to LC for each condition (t-test; p < 0.05). (B) Fold changes in gene expression of loaded limb normalized to control limbs are shown. Asterisk indicates a significant difference between loaded and control bones for each condition (paired t-test; p < 0.05). (C) Fold changes in gene expression of 26 week old mice normalized to 10 week old mice are shown. Asterisk indicates a significant difference between 26 and 10 week old mice for each condition (t-test; p < 0.05).
