Table 2 Endocortical (Ec) and periosteal (Ps) bone parameters of the tibial midshaft determined by dynamic histomorphometry, based on fluorochrome injections administered on days 3 and 12.
LC mice | Sost KO mice | |||||||
---|---|---|---|---|---|---|---|---|
10 wk old | 26 wk old | 10 wk old | 26 wk old | |||||
Control | Loaded | Control | Loaded | Control | Loaded | Control | Loaded | |
Outcome | (n = 7) | (n = 7) | (n = 7) | (n = 7) | (n = 6) | (n = 7) | (n = 7) | (n = 7) |
Ec.sLS/BS (%) b, f | 20.6 ± 7 | 11.9 ± 4.6 | 28.1 ± 7.4* | 38.7 ± 10.1 | 23.6 ± 20.4 | 7.3 ± 7.6 | 27.7 ± 15.4 | 23.5 ± 9.3 |
Ec.dLS/BS (%) a, b, c, e | 53.1 ± 11.3* | 68.2 ± 7.7 | 19 ± 10 | 20.2 ± 10.8 | 66.5 ± 19.8* | 84.6 ± 9.2 | 33.8 ± 6.3* | 55.3 ± 13.5 |
Ec.MS/BS (%) a, b, c | 63.5 ± 10.9* | 74.2 ± 8 | 33.1 ± 9.3 | 39.5 ± 9.5 | 78.3 ± 11.4* | 88.2 ± 7.7 | 47.6 ± 8.5* | 67.1 ± 10.8 |
Ec.MAR (μm/day) a, b, c | 1.21 ± 0.21* | 1.5 ± 0.21 | 0.94 ± 0.22 | 1.11 ± 0.2 | 1.22 ± 0.16* | 1.61 ± 0.15 | 1.24 ± 0.41 | 1.61 ± 0.38 |
Ec.BFR/BS (μm³/μm²/day) a, b, c, e | 0.76 ± 0.12* | 1.11 ± 0.19 | 0.32 ± 0.12 | 0.45 ± 0.17 | 0.94 ± 0.08* | 1.42 ± 0.16 | 0.57 ± 0.13* | 1.08 ± 0.29 |
Ps.sLS/BS (%) a, e | 25.6 ± 12 | 28.7 ± 14 | 21.3 ± 4.8 | 24.9 ± 16.9 | 49.4 ± 25.6 | 12.4 ± 13.2 | 35 ± 8.2 | 37.1 ± 10.7 |
Ps.dLS/BS (%) a, b, c, e | 13.3 ± 7.5 | 19.6 ± 13.2 | 1.9 ± 1.6* | 4.8 ± 3 | 13.4 ± 7.5* | 83.2 ± 19.4 | 16 ± 10.2* | 59.1 ± 13.8 |
Ps.MS/BS (%) a, b, c, e | 22.4 ± 13.2* | 34 ± 9.9 | 11.9 ± 3.6 | 16.5 ± 8.2 | 33.6 ± 15.4* | 89.4 ± 12.8 | 31.2 ± 11.5* | 77.7 ± 8.7 |
Ps.MAR (μm/day) a, b, c, e | 0.92 ± 0.33 | 0.89 ± 0.31 | 0.57 ± 0.13 | 0.72 ± 0.22 | 0.95 ± 0.19* | 1.63 ± 0.1 | 0.63 ± 0.08* | 1.09 ± 0.11 |
Ps.BFR/BS (μm³/μm²/day) a, b,c, e, f | 0.28 ± 0.17 | 0.32 ± 0.16 | 0.07 ± 0.02 | 0.13 ± 0.09 | 0.34 ± 0.21* | 1.46 ± 0.23 | 0.21 ± 0.08* | 0.84 ± 0.09 |