Figure 3 | Scientific Reports

Figure 3

From: Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

Figure 3

Effects of QE on the production of ECM in C57 mice with liver fibrosis induced by BDL or CCl4. Notes: (A) The levels of serum HA, LN and collagen I and α-SMA measured with ELISAs were reduced by quercetin treatment in mice at doses of 100 mg/kg and 200 mg/kg. Data are presented as means ± SD (n = 8, *P < 0.05 for sham or vehicle versus model group, #P < 0.05 for BDL(CCl4) + QE100 versus model groups, and +P < 0.05 for BDL(CCl4) + QE200 versus model groups). (B) Quercetin changed the expression of Collagen I, α-SMA, MMP-9 and TIMP-1, which were detected by western blot. (C) The mRNA expression of LN, HA, Collagen I and α-SMA were measured by qRT-PCR. Data are presented as means ± SD (n = 8, *P < 0.05 for sham or vehicle versus model group, #P < 0.05 for BDL(CCl4) + QE100 versus model groups, and +P < 0.05 for BDL(CCl4) + QE200 versus model groups). (D) Immunohistochemistry staining(×200) showing the expression of Collagen I and α-SMA in liver tissue, which were reduced by quercetin treatment.

Back to article page