Figure 6 | Scientific Reports

Figure 6

From: Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

Figure 6

Effects of QE on autophagy in liver fibrosis. Notes: (A) The mRNA levels of Beclin-1 and LC3 were decreased by quercetin in a dose-depended manner. Data are presented as means ± SD (n = 8, *P < 0.05 for sham or vehicle versus model group, #P < 0.05 for BDL(CCl4) + QE100 versus model groups, and +P < 0.05 for BDL(CCl4) + QE200 versus model groups). (B) Quercetin effectively changed the expression of Beclin-1,LC3 and P62, which were detected by western blot. (C) Immunohistochemistry staining(×200) showed the expression of Beclin-1 and LC3 in liver tissues. (D) The formation of autophagosomes was shown by TEM(original magnificantion:1.2k for sham and vehicle;3.0k for model groups and treatment groups).

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