Figure 4 | Scientific Reports

Figure 4

From: Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy

Figure 4

Kinetics of adenosine uptake mediated by ENTs are affected by D-glucose and insulin. Primary cultured podocytes were exposed to 5mM or 25mM D-glucose for 24 h and supplemented with 10nM insulin the last 30 minutes. Adenosine transport activity (0–500 µM adenosine, 60 seconds to 22 °C) mediated by ENT1 (A) and ENT2 (B) were measured. Data were adjusted to Michaelis-Menten equations without a lineal component. Graphs represent means ± S.E. n = 9.

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