Figure 3

Fas-mediated liver injury in Ripk1 ^LPC-KO mice is independent of TNF-α. (a) Levels of serum ALT and AST (n = 4–10) in Ripk1^LPC-KO mice after 3 or 6 h mAb-Jo2 injection with a possible pre-treatment with ETA (ns: non-significant). Each circle or dot represent an individual. (b) Pictures of liver tissue sections, stained by H&E (upper panels) or analysed by IHC for cleaved caspase-3 (lower panels), issued from Ripk1^LPC-KO mice, 6 h after mAb-Jo2 injection with a possible pre-treatment with ETA. Signal quantification of cleaved caspase-3 (lower right panel).