Figure 5
From: RIPK1 protects hepatocytes from death in Fas-induced hepatitis
Co-administration of IFN-γ and TRAIL promotes liver injury in Ripk1 LPC-KO mice in a TNF-α dependent manner. (a) Levels of serum ALT, 8 h after TRAIL or PBS injection with a possible pre-treatment with IFN-γ and/or ETA in Ripk1 fl/fl and Ripk1 LPC-KO mice (n = 3–6 mice). Each circle represents an individual. (b) Pictures of liver tissue sections, stained by H&E (upper panels) or analysed by IHC for cleaved caspase-3 (lower panels), issued from Ripk1 fl/fl and Ripk1 LPC-KO mice, 8 h after TRAIL injection, pre-treated 2 h before with IFN-γ and with a possible pre-treatment with ETA. Yellow and black arrows respectively show necrotic areas and apoptotic hepatocytes, PV: portal vein.
