Table 3 Association between the risk of liver cirrhosis development and diabetes duration, diabetes treatment, diabetes complications, and other variables in diabetes patients.

From: Diabetes mellitus is a significant risk factor for the development of liver cirrhosis in chronic hepatitis C patients

Variables

Liver cirrhosis N = 45

CHC-only N = 62

P #

AOR (95% CI)*

P**

Sex

  

0.065

0.415 (0.178–0.969)

0.042

 Female, N (%)

27 (60.0)

26 (41.9)

   

 Male, N (%)

18 (40.0)

36 (58.1)

   

Age

  

0.554

 <50

6 (13.3)

6 (9.7)

   

 ≥50

39 (86.7)

56 (90.3)

   

Duration of diabetes

  

0.873

-

 ≤5 years, N (%)

34 (75.6)

46 (74.2)

   

 >5 years, N (%)

11 (24.4)

16 (25.8)

   

Diabetes treatment

  

0.836

 No, N (%)

22 (48.9)

30 (48.4)

   

 single drug, N (%)

23 (51.1)

31 (50.0)

   

 multiple drugs, N (%)

0

1 (1.6)

   

Diabetic retinopathy

  

0.023

 No, N (%)

44 (97.8)

52 (83.9)

   

 Yes, N (%)

1 (2.2)

10 (16.1)

   

Diabetic neuropathy

  

1.000

 No, N (%)

45 (100.0)

61 (98.4)

   

 Yes, N (%)

0 (0.0)

1 (1.6)

   

Diabetic nephropathy

  

0.571

 No, N (%)

43 (95.6)

61 (98.4)

   

 Yes, N (%)

2 (4.4)

1 (1.6)

   

Triglycerides

  

0.017

0.268 (0.079–0.910)

0.035

 ≤1.8 mmol/L, N (%)

41 (91.1)

45 (72.6)

   

 >1.8 mmol/L, N (%)

4 (8.9)

17 (27.4)

   

Cholesterol

  

1.000

 ≤6.0 mmol/L, N (%)

42 (93.3)

58 (93.5)

   

 >6.0 mmol/L, N (%)

3 (6.7)

4 (6.5)

   

Gallstones

  

0.004

4.938 (1.524–15.998)

0.008

No, N (%)

32 (71.1)

57 (91.9)

   

Yes, N (%)

13 (28.9)

5 (8.1)

   
  1. CHC = chronic hepatitis C; AOR = adjusted odds ratio; CI = confidence interval.
  2. Continuous variables are expressed as median (25th, 75th percentiles).
  3. # P value for univariate analysis.
  4. *Adjusted for sex, age, duration of diabetes, diabetes treatment, diabetic retinopathy, diabetic neuropathy, diabetic nephropathy, triglycerides, cholesterol, gallstones, and liver cirrhosis.