Table 1 Map location of the mutations characterizing the mitogenomes of the PD61, PD63 and PD67 cybrids.

From: A missense MT-ND5 mutation in differentiated Parkinson Disease cytoplasmic hybrid induces ROS-dependent DNA Damage Response amplified by DROSHA

MAP Locusa

PD61b GenBank: KY498629 Haplogroup: L2e1a

PD63b GenBank: KY498630 Haplogroup: H1a3b

PD67b GenBank: KY498631 Haplogroup: H3b1b1

MT-RNR1

G719A A750G G769A C954T G1018A A1171h G1211A A1438G

A750G A1438G

A750G A1438G

MT-RNR2

T2416C A2706G

G3010A

A2581G

MT-ND1

A3537G C3594T C4086T A4104G

  

MT-ND2

A4562G A4769G A5069T (M200I)

A4769G

A4769G G5147A

MT-CO1

T6014C C6617T C7028T C7256T

 

T6776C A7403G

MT-TD

G7521A

  

MT-ATP8

T8383C

  

MT-ATP6

A8701G (T59A) A8860G (T112A) G8994A

A8860G (T112A)

A8860G (T112A)

MT-CO3

A9221G A9377G T9540C C9971T

  

MT-ND3

T10115C A10398G (T114A)

  

MT-ND4

G10873C G11149A G11719A T11935C A11989G

  

MT-TH

T12189C

  

MT-TS2

G12236A

  

MT-ND5

C12705T G13194A G13590A C13650T G13708A (A458T)

G13804h (A490T)

G13813A (V493I)

MT-ND6

C14266T T14299C

  

MT-CYB

C14766T (T7S) G15301A A15326G (T194A) T15697C G15734A (A330T)

A15326G (T194A)

A15326G (T194A)

MT-TT

T15889C

  

MT-DLOOP

C16111A G16145A C16184T T16189C C16223T C16239T C16278T C16292T C16355T G16390A A16399G C16400T T16519C A73G T146C C150T T152C C182T A183G A263G 309.1 C 315.1 C A479G

A16051G A16162G A16241C C16465T T16519C A73G T195C A263G 315.1 C A522d C523d

C16111T G16129A C16256T T16519C T146C A153G A263G 309.2 C 315.1 C

  1. aMap locus nomenclature is according to https://www.mitomap.org/MITOMAP.
  2. bMutations are relative to the revised Cambridge Reference Sequence (rCRS)61. Heteroplasmic nucleotide positions are marked by an “h”, deletions by a “d”, while insertions are indicated by “.” followed by number and type of inserted nucleotide(s). All observed mutations in the mtDNA coding region (from np 577 to np 16023) are diagnostic of the corresponding haplogroup except those underlined. For non-synonymous mutations the amino acid change is reported in brackets.
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