Figure 2

Deconvolution of habitats in a simulated dataset with mixed voxels. (A) Representative images of D ^mixed(r, t) (SNR of 2.5) at selected time points (from 0 to 250 s with increments of 50 s); (B) Map showing the distribution of weights in each voxel for well-perfused, hypoxic, and necrotic habitats in D ^mixed(r, t), as indicated by the level of red, green, and blue, respectively; (C,D) Results from cNMF after seeking three solutions in D ^mixed(r, t) at an SNR of 2.5 and 10, respectively. The number of solutions sought was automated through the combined test, which indicated the number of curves present in the dataset; (E,F) cNMF weights showing the spatial distribution of the recovered well-perfused, hypoxic, and necrotic signal-versus-time curves (left to right) for D ^mixed(r, t) at an SNR of 2.5 and 10, respectively.