Figure 8 | Scientific Reports

Figure 8

From: Estrogen receptor α/HDAC/NFAT axis for delphinidin effects on proliferation and differentiation of T lymphocytes from patients with cardiovascular risks

Figure 8

Summary of the mechanisms of the biological effects of delphinidin on T lymphocytes. Delphinidin inhibits ERK1/2, NFAT and HDAC pathways activation, also it decreases [Ca2+]i augmentation by inhibiting intracellular Ca2+ release and extracellular Ca2+ entry through CRAC channels. These effects occur mostly via ERα-dependent mechanism resulting in inhibition of proliferation and differentiation of T lymphocytes.

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