Table 2 The pooled values for background characteristics, symptoms, MRI findings, and laboratories.

Male (%)

7, 260

68.6 (58.4 to 78.8)%, 63%

4, 167

63.4 (49.2 to 46.9)%, 66%

7, 93

72.1 (58.1 to 42.4)%, 55%

0.39, 0%

Onset of BD (year old)

5, 254

39.0 (35.0 to 43.0)%, 83%

4, 167

39.2 (31.5 to 46.9)%, 92%

5, 87

39.3 (36.2 to 42.4)%, 34%

0.99, 0%

Onset of NBD (year old)

5, 254

42.9 (36.3 to 49.6)%, 93%

4, 167

43.1 (26.7 to 59.4)%, 96%

5, 87

43.3 (40.7 to 45.9)%, 0%

0.98, 0%

HLA-B51 positive (%)

4, 193

53.0 (35.4 to 70.6)%, 84%

2, 122

46.2 (36.7 to 55.7)%, 17%

4, 71

56.1 (24.8 to 87.4)%, 88%

0.55, 0%

Smoking (%)

1, 102

80.0 (58.4 to 100)%, 88%

1, 68

69.0 (58.2 to 79.8)%, NA

1, 34

91.0 (80.2 to 100)%, NA

0.005, 87.5%

Cyclosporin use (%)

1, 27

18.3 (0 to 48.8)%, 95%

1, 26

34.0 (23.6 to 44.4)%, NA

1, 1

2.9 (0 to 11.1)%, NA

<0.001, 95.3%

Fever (%)

1, 111

29.6 (0 to 82.2)%, 98%

1, 76

56.6 (45.7 to 67.5)%, NA

1, 35

2.9 (0 to 11.2)%, NA%

<0.001, 98.3%

Headache (%)

5, 248

40.7 (18.5 to 62.9)%, 94%

3, 164

45.1 (20.5 to 69.7)%, 90%

5, 84

38.9 (7.8 to 70.0)%, 92%

0.76, 0%

Cranial nerve disorder (%)

2, 123

28.3 (16.2 to 40.5)%, 46%

2, 81

27.3 (17.9 to 36.8)%, 0%

2, 42

36.6 (0 to 76.4)%, 81%

0.66, 0%

Confusion (%)

2, 133

8.5 (0.6 to 16.3)%, 35%

2, 88

4.7 (0 to 10.1)%, 0%

2, 45

17.6 (6.3 to 28.8)%, 0%

0.04, 76%

Dizziness (%)

3, 131

34.4 (2.4 to 66.4)%, 97%

2, 86

43.9 (0 to 100)%, 97%

3, 45

26.0 (0 to 53.1)%, 80%

0.62, 0%

Dementia (%)

3, 28

36.7 (9.8 to 63.7)%, 75%

2, 13

12.6 (0 to 44.3)%, 60%

3, 15

53.4 (34.4 to 72.4)%, 0%

0.03, 78.6%

Dysarthria (%)

1, 111

29.8 (6.0 to 53.6)%, 0%

1, 76

18.5 (9.8 to 27.3)%, NA

1, 35

42.9 (27.3 to 58.5)%, NA

0.008, 85.9%

Sensory disorder (%)

3, 135

20.8 (8.5 to 33.0)%, 57%

2, 88

13.5 (0 to 37.2)%, 82%

3, 47

27.3 (11.8 to 42.7)%, 26%

0.34, 0%

Cerebellar sign (%)

2, 10

81.7 (61.5 to 100)%, 0%

1, 3

66.7 (29.6 to 100)%, NA

2, 7

88.0 (63.9 to 100)%, 0%

0.34, 0%

Pyramidal sign (%)

2, 10

92.0 (72.5 to 100)%, 0%

1, 3

100.0 (66.3 to 100)%, NA

2, 7

88.0 (63.9 to 100)%, 0%

0.57, 0%

Seizure (%)

1, 115

1.7 (0 to 5.5)%, 0%

1, 78

2.6 (0 to 7.2)%, NA

1, 37

0.0 (0 to 6.5)%, NA

0.53, 0%

Hemiparesis (%)

1, 18

4.9 (0 to 19.9)%, 0%

1, 10

10.0 (0 to 31.5)%, NA

1.8

0.0 (0 to 21.0)%, NA

0.51, 0%

Sphincter disturbance (%)

2, 226

13.9 (3.5 to 24.4)%, 82%

2, 154

7.9 (0 to 19.1)%, 83%

2, 72

21.6 (12.0 to 31.3)%, 5%

0.07, 69.8%

Ataxia (%)

4, 230

38.0 (21.3 to 54.7)%, 87%

2, 154

16.5 (6.7 to 26.2)%, 63%

4, 76

53.3 (32.0 to 74.7)%, 70%

0.002, 89.5%

Normal (%)

3, 135

31.5 (9.3 to 53.7)%, 91%

2, 88

34.3 (0 to 86.2)%, 95%

3, 47

28.7 (0 to 62.0)%, 85%

0.86, 0%

Brain stem any finding (%)

7, 160

62.4 (44.3 to 80.6)%, 84%

4, 102

59.7(28.9 to 90.4)%, 90%

6, 58

64.8 (38.1 to 91.4)%, 82%

0.81, 0%

Brain stem atrophy (%)

4, 32

49.1 (13.5 to 84.8)%, 87%

2, 15

11.9 (0 to 29.9)%, 0%

3, 17

76.3 (47.2 to 100)%, 65%

 < 0.001, 93%

Cerebellum (%)

5, 144

26.5 (9.7 to 43.3)%, 90%

3, 93

3.5 (0 to 8.5)%, 0%

5, 51

51.3 (8.7 to 93.8)%, 93%

0.03, 79.1%

Thalamus (%)

3, 33

10.5 (0 to 22.4)%, 7%

2, 12

12.8 (0 to 44.6)%, 0%

3, 21

12.6 (0 to 27.7)%, 4%

0.99, 0%

White matter (%)

2, 29

22.3 (0 to 47.2)%, 70%

2, 21

15.9 (0 to 48.6)%, 78%

1, 8

37.5 (9.4 to 65.6)%, NA

0.33, 0%

Basal ganglia (%)

3, 127

40.5 (15.8 to 65.2)%, 90%

2, 84

48.2 (0 to 98.6)%, 94%

2, 43

35.3 (9.4 to 65.6)%, 91%

0.72, 0%

CSF cell count (/mm³

5, 286

78.6 (48.2 to 108.9)%, 98%

4, 190

156.2 (53.8 to 258.7)%, 97%

5, 96

27.2 (0 to 54.4)%, 98%

0.02, 82.4%

CSF IL-6 (pg/mL)

4, 64

77.2 (31.8 to 122.5), 97%

2, 36

65.4 (0 to 161.3), 99%

4, 28

95.9 (21.5 to 170.2), 86%

0.62, 0%

CSF protein (mg/dL)

3, 266

89.4 (72.1 to 106.8), 99%

3, 180

112.9 (75.4 to 150.4), 99%

3, 86

78.9 (50.8 to 107.0), 99%

0.16, 50.4%