Figure 6 | Scientific Reports

Figure 6

From: Synergistic impact of mutations in Hepatitis B Virus genome contribute to its occult phenotype in chronic Hepatitis C Virus carriers

Figure 6

Effects of mutations in PreS2 and X-ORFs as well as in Enh-II on generation of ER stress by analyzing GRP78-promoter activity. The full-length, wild-type HBV (HBV/D-wt) along with the mutant variants harbouring mutations in (i) PreS2 and X-ORF [HBV/D-mt(PreS2 + HBX)] and (ii) Enh-II element [HBV/D-mt(Enh-II)] were co-transfected with pGL3-GRP78-promoter construct separately in Huh7 cells and the relative luciferase activities were determined after 48 hrs. Paired t-test p values; *p < 0.05.

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