Figure 9

Effects of LDN193189 on the phosphorylation level of Smad1/5/8 and the expression level of matrix protein (MP) genes in mantle primary cells. (A) Changes in phosphorylated Smad1/5/8 in mantle cells detected by western blot. p-Smad1/5/8: Phosphorylated Smad1/5/8. β-Actin is used as control. (B) The relative expression levels of MP genes in the mantle cells exposed to LDN193189. The expression levels of MP genes in unexposed mantle cells were used as corresponding controls. *P < 0.05. Differences were assessed by one-way ANOVA.