Figure 3 | Scientific Reports

Figure 3

From: Structural and Functional View of Polypharmacology

Figure 3

Conservation of the binding site within CATH-FunFams. Structural alignment of the CATH-Funfams associated with: (A) acetazolamide (CATH ID: 3.10.200.10-FF1430), (B) nilotinib (CATH ID: 1.10.510.10-FF78758), (C) Sildenafil (CATH ID: 1.10.510.10-FF78946), (D) tadalafil (CATH ID: 1.10.1300.10-FF1260), (E) Tretinoin (CATH ID: 1.10.565.10-FF5060) and (F) vorinostat (CATH ID: 3.40.800.20-FF2855) and the drug-target complexes of these drugs. In each case, the protein domain is grey, except the ligand binding residues, which have been coloured yellow. The drug molecules are coloured in rainbow.

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