Figure 2
From: Structure-based drug discovery for combating influenza virus by targeting the PA–PB1 interaction
Direct binding between PA protein and hit compounds. Compounds selected by cell-based screening were subjected to surface plasmon resonance analysis. Anti-PA antibody was immobilised on the sensor chip and captured the recombinant PA protein before various concentrations of compounds were loaded as analytes. (a) Sensorgram and (b) fitting curves from the sensorgram were shown.
