Table 2 Summary of the phylogenetic distribution of the Giardia’s absent GPL biosynthesis enzymes in other organisms.
Organism | PA pathway | CDP-DAG pathway | Kennedy Pathway | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Gpd1/Gpd2(NAD+) | Sct1/Gpt2 | Pgs_pld | Cls_cap | Cls_pld | Pem1/Pem2 | Psse1/Psse2 | Ect/Pct | Ept/Cpt | ||
Bacteria* | + | + | − | + | + | −/− | − | − | − | |
Archaea** | + | + | − | − | + | +/− | − | − | − | |
Excavata | Giardia lamblia (P) | − | − | − | − | − | −/− | − | − | − |
Trichomonas vaginalis (P) | + | − | − | − | − | −/+ | + | + | + | |
Trypanosoma brucei (P) | + | + | + | − | + | −/− | + | + | + | |
Leishmania major (P) | + | + | + | − | + | +/+ | + | + | + | |
Bodo saltans (F) | + | + | + | − | + | +/+ | + | + | + | |
Naegleria gruberi (F) | + | + | + | − | + | +/+ | + | + | + | |
Amoebozoa | Entamoeba dispar (P) | − | − | − | − | − | −/+ | + | + | + |
Entamoeba histolytica (P) | − | − | − | − | − | −/+ | + | + | + | |
Acanthamoeba castellanii (F) | + | + | + | + | + | +/+ | + | + | + | |
