Table 1 Subject demographics.

Age, years^a

62.5 ± 7.5

67.0 ± 9.1*

71.3 ± 7.3*

78.1 ± 4.7*^†^

Female, n (%)^b

40 (71.4)

26 (65.0)

15 (46.9)

17 (73.9)

Education years^a

12.5 ± 5.0

10.4 ± 5.3

8.6 ± 4.6*

9.1 ± 5.5*

WMH volume (cm³)^a

0.72 ± 0.92

3.18 ± 6.04

39.29 ± 14.71^†

45.54 ± 22.91^†

Lacune, number^c

0 (0, 0)

0 (0, 0)

13 (8.3, 33.3)^†^

5 (2, 10)

Microbleed, number^c

0 (0, 0)

0 (0, 0)

5.5 (1.0, 13.5)^†

1 (0, 6)^†

MMSE^a

28.8 ± 1.4

17.4 ± 6.1*

21.6 ± 4.6*^†^

18.7 ± 4.9*

CDR-SOB^a

0.58 ± 0.45

4.85 ± 2.29*

5.97 ± 3.84*

6.54 ± 3.76*