Figure 5 | Scientific Reports

Figure 5

From: TGF-β participates choroid neovascularization through Smad2/3-VEGF/TNF-α signaling in mice with Laser-induced wet age-related macular degeneration

Figure 5

TGF-β inhibitor LY2157299 could dose-dependently inhibit the Laser-induced CNV formation at in RPE-choroid-sclera complex of mice. The representative images showed CNV staining with isolectin-B4 in the RPE-choroid-sclera complex of Laser-treated mice at 2 weeks after intraperitoneal injections of PBS (A) and LY2157299 at 1.5 (B), 3.0 (C) and 6.0 μg/g BW (D). (E) The statistical results suggest that LY2157299 (3.0–6.0 μg/g BW) could significantly inhibit Laser-induced neovascular growth when compared with that of PBS treatment. *P < 0.05 vs PBS treatment; bars = 100 μm; n = 5 per group.

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