Table 1 Blood and urinary glucose levels, daily water intake, body weights and relative kidney weights of the study groups.

From: Cinaciguat ameliorates glomerular damage by reducing ERK1/2 activity and TGF-ß expression in type-1 diabetic rats

Parameter

Co

Co-Cin

DM

DM-Cin

Pdiabetes

Ptreatment

Pinteraction

Blood glucose (mmol l−1)

5.7 ± 0.4

6.1 ± 0.2

30.2 ± 1.6a,b

30.3 ± 3.5a,b

<0.001

0.698

0.748

Daily water intake (ml day−1)

33.4 ± 2.4

37.9 ± 2.6

239.8 ± 14.2a,b

154.9 ± 15.7a,b,c

<0.001

<0.001

<0.001

Body weight (g)

480 ± 60

478 ± 72

280 ± 27a,b

254 ± 46a,b

<0.001

0.530

0.351

Kidney weight/body weight (mg g−1)

2.5 ± 0.4

2.6 ± 0.3

5.6 ± 0.4a,b

5.9 ± 0.6a,b

<0.001

0.265

0.305

Mean arterial blood pressure (mmHg)

79.6 ± 6.8

80.1 ± 12.1

63.7 ± 8.5a,b

64.4 ± 9.8a,b

<0.001

0.845

0.969

  1. Values are presented as mean ± SD (n = 10–12/group). ap < 0.05 vs. Co; bp < 0.05 vs. Co-Cin; cp < 0.05 vs. DM (two-way ANOVA with Sidak’s multiple comparisons test).