Table 5 Odds ratios (OR) of knee pain and clinical KOA associated with serum lipid levels in the cross-sectional analysis (N = 13,906).

From: The cross-sectional and longitudinal effect of hyperlipidemia on knee osteoarthritis: Results from the Dongfeng-Tongji cohort in China

Variables

ORs increase per 1-unit increase in serum lipid levels

ORs for the levels of serum lipid versus the normal group

Group 1

Group 2

Group 3: With hyperlipidemia and use of lipid-lowering drugs

Group 4: Without hyperlipidemia but taking lipid-lowering drugs for prevention of other diseases

Knee pain

  TC

1.08 (1.05–1.12)*

Reference

1.07 (0.99–1.16)

1.42 (1.28–1.58)*

1.04 (0.86–1.25)

  TG

1.05 (1.01–1.08)*

Reference

1.11 (1.02–1.21)*

1.43 (1.28–1.58)*

1.04 (0.87–1.26)

  LDL-C

1.06 (1.02–1.11)*

Reference

1.07 (0.98–1.18)

1.40 (1.27–1.56)*

1.03 (0.86–1.24)

  HDL-C

1.03 (0.93–1.14)

Reference

0.90 (0.80–1.01)

1.36 (1.23–1.51)*

1.00 (0.83–1.20)

Clinical KOA

  TC

1.06 (0.99–1.13)

Reference

1.03 (0.88–1.20)

1.54 (1.28–1.85)*

1.01 (0.70–1.46)

  TG

1.09 (1.04–1.14)*

Reference

1.12 (0.94–1.32)

1.57 (1.30–1.88)*

1.04 (0.72–1.49)

  LDL-C

0.98 (0.91–1.07)

Reference

1.03 (0.86–1.24)

1.53 (1.28–1.83)*

1.01 (0.70–1.45)

  HDL-C

0.97 (0.80–1.19)

Reference

0.85 (0.66–1.09)

1.49 (1.24–1.78)*

0.98 (0.69–1.41)

  1. TC: total cholesterol. TG: triglyceride. LDL-C: low-density lipoprotein cholesterol. HDL-C: high-density lipoprotein cholesterol.
  2. TC: group 1, <5.18 mmol/L and without lipid-lowering drugs; group 2, ≥5.18 mmol/L and without lipid-lowering drugs.
  3. TG: group 1, <1.70 mmol/L and without lipid-lowering drugs; group 2, ≥1.70 mmol/L and without lipid-lowering drugs.
  4. LDL-C: group 1, <3.37 mmol/L and without lipid-lowering drugs; group 2, ≥3.37 mmol/L and without lipid-lowering drugs.
  5. HDL-C: group 1, ≥1.04 mmol/L and without lipid-lowering drugs; group 2, <1.04 mmol/L and without lipid-lowering drugs.
  6. Adjusted for age (as a continuous variable), WHR (as a continuous variable), and gender. * p-value < 0.05.
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