Figure 5

Model predictions for combination therapy. We simulate a short treatment (7 days) of LASV infected mice with combinations of 150 mg/kg favipiravir and 80 mg/kg ribavirin (a), 150 mg/kg favipiravir and 80 mg/kg ribavirin (b); and a long treatment period (11 days) with a combination of 150 mg/kg favipiravir and 80 mg/kg ribavirin (c). All treatment started at day 4 p.i.. Solid gray lines depict the median prediction out of 1000 simulations for VL (upper row) and AST (lower row) based on parameter ranges obtained for model C (Table 1). Shaded areas represent the 90% predictive intervals. Red circles represent the experimental data for the corresponding treatment regime as measured in ref.⁷.