Table 1 Parameter estimates for viral dynamic models of favipiravir and ribavirin during LASV infection. T 0 = 106 cells/ml.
From: Determining Ribavirin’s mechanism of action against Lassa virus infection
Parameters | Model A mean (r.s.e) | Model B mean (r.s.e) | Model C mean (r.s.e) | Model D mean (r.s.e) | Model C1 mean (r.s.e) | Model C2 mean (r.s.e) | Model C3 mean (r.s.e) |
|---|---|---|---|---|---|---|---|
V 0 (FFU/ml) | 10.00 | 10.00 | 10.00 | 10.00 | 10.00 | 10.00 | 10.00 |
T 0 (cells/ml) | 106 | 106 | 106 | 106 | 106 | 106 | 106 |
c (/day) | 20.00 | 20.00 | 20.00 | 20.00 | 20.00 | 20.00 | 20.00 |
c A (/day) | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
R 0 | 6.72 (20) | 6.08 (19) | 4.96 (13) | 5.86 (16) | 5.62 (16) | 4.92 (12) | 4.62 (12) |
δ I (/day) | 0.48 (23) | 0.53 (22) | 0.60 (16) | 0.54 (19) | 0.54 (19) | 0.67 (15) | 0.71 (14) |
p (FFU/day) | 3.52 (27) | 3.9 (27) | 1.82 (22) | 4.06 (25) | 3.09 (24) | 3.19 (22) | 2.34 (24) |
α (×10−4) | 14.1 (17) | 12.3 (18) | 18.0 (15) | 11.2 (21) | 22.0 (16) | 23.0 (14) | 19.3 (13) |
s x (U/l) | 71.80 (6) | 72.50 (6) | 66.80 (6) | 74.40 (6) | 71.30 (6) | 66.50 (6) | 66.40 (6) |
\({{\rm{ED}}}_{{\rm{50}}}^{{\rm{F}}}\)(mg/kg) | 1.61 (50) | 1.85 (52) | 3.9 (49) | 1.89 (46) | 2.3 (47) | 3.2 (46) | 4.01 (47) |
\({{\rm{ED}}}_{{\rm{50}}}^{{\rm{R}}}\)(mg/kg) | 75.30 (36) | 164.00 (31) | 6.71 (37) | 4.4×105 (510) | 9.05 (41) | 4.93 (28) | 6.95 (30) |
\({{\rm{ED}}}_{{\rm{50,2}}}^{{\rm{R}}}\) (mg/kg) | 6.05 × 103 (513) | 73.80 (23) | 72.8 (30) | ||||
σ a (log10 FFU/ml) | 0.61 (7) | 0.62 (7) | 0.71 (7) | 0.59 (7) | 0.65 (8) | 0.64 (7) | 0.67 (7) |
σ b (U/l) | 0.31 (9) | 0.31 (9) | 0.22 (11) | 0.32 (9) | 0.27 (9) | 0.21 (10) | 0.21 (11) |
BIC | 2214.69 | 2219.70 | 2129.41 | 2227.8 | 2184.87 | 2146.22 | 2152.37 |
