Table 4 Sensitivity analysis for different values of Hill coefficients nR for ribavirin in model C.
From: Determining Ribavirin’s mechanism of action against Lassa virus infection
nF = 1 | nF = 3.5 | ||||||
|---|---|---|---|---|---|---|---|
nR = 2 | nR = 3 | nR = 4 | nR = 1 | nR = 2 | nR = 3 | nR = 4 | |
R 0 | 5.13 (12) | 4.66 (11) | 5.29 (12) | 4.77 (12) | 5.29 (10) | 4.88 (9) | 5.72 (13) |
δ I (/day) | 0.58 (14) | 0.65 (14) | 0.56 (13) | 0.63 (14) | 0.56 (15) | 0.62 (10) | 0.52 (14) |
p (FFU/day) | 1.88 (20) | 2.02 (19) | 1.89 (17) | 1.86 (21) | 1.84 (17) | 2.04 (18) | 1.84 (18) |
α (×10−4) | 18.2 (15) | 17.5 (14) | 18.5 (15) | 18.2 (14) | 1.81 (14) | 16.5 (15) | 17.2 (15) |
s x (U/l) | 67.1 (6) | 67.2 (6) | 68.1 (6) | 66.9 (6) | 66.6 (6) | 67.4 (6) | 67.9 (6) |
\({{\rm{ED}}}_{{\rm{50}}}^{{\rm{F}}}\) (mg/kg) | 3.46 (49) | 4.88 (47) | 3.43 (46) | 5.61 (30) | 38.6 (13) | 43.3 (9) | 39.2 (14) |
\({{\rm{ED}}}_{{\rm{50}}}^{{\rm{R}}}\) (mg/kg) | 26.2 (15) | 40.9 (11) | 51.4 (11) | 44.9 (14) | 26 (15) | 43.3 (13) | 54 (11) |
σ a (log10 FFU/ml) | 0.698 (7) | 0.683 (8) | 0.679 (7) | 0.74 (7) | 0.731 (7) | 0.71 (7) | 0.678 (7) |
σ b (U/l) | 0.219 (11) | 0.221 (11) | 0.238 (11) | 0.22 (11) | 0.226 (11) | 0.22 (11) | 0.238 (11) |
BIC | 2193.73 | 2133.3 | 2146.5 | 2135.41 | 2136.98 | 2137.46 | 2145.93 |
