Figure 1 | Scientific Reports

Figure 1

From: Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice

Figure 1

Spontaneous development of atopic keratoconjunctivitis (AKC)-like lesions in hK14mIL33tg (IL33tg) mice. (a,b) Keratoconjunctival manifestations (a) and fluorescein staining of cornea (b) of wild-type (WT) and hK14mIL33tg (IL33tg) mice (Tg). Representative photographs taken from at least six 24- to 30-week-old mice are shown. Similar keratoconjunctival lesions were observed in three independent experiments. (c) Incidence of spontaneous keratoconjunctivitis that develops in IL33tg mice. Keratoconjunctivitis developed spontaneously between 18 and 22 weeks of age and remained thereafter in all IL33tg mice. WT mice (n = 11), IL33tg mice (Tg) (n = 17). P < 0.0001 by the two-tailed log-rank test. (d,e) Immunofluorescence of IL-33 in the ocular surface epithelium of WT and IL33tg mice (Tg). Intense staining of IL-33 was evident in nuclei of the conjunctival epithelium (d) and corneal epithelial cells (e) in 20- to 30-week-old IL33tg mice. Bars, 50 µm. Data are representative of three independent experiments.

Back to article page