Figure 2 | Scientific Reports

Figure 2

From: Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice

Figure 2

Keratoconjunctivitis with eosinophil infiltrates in 20- to 30-week-old IL33tg mice. (a–c) H&E staining of WT and IL33tg mouse (Tg) conjunctiva and cornea. Cell infiltrations including eosinophils (arrowheads) were evident in the conjunctiva (b) and the corneal stroma (c) of IL33tg mice. Panels are representative of six mice and of three independent experiments. (a) The whole eye (upper panels). Bars, 500 µm; the eyelid (lower panels). Bars, 200 µm. (b) The conjunctiva. Bars, 100 µm. (c) The cornea. Bars, 50 µm. (d,e) Toluidine blue staining of WT and IL33tg mouse (Tg) conjunctiva and cornea. Toluidine blue-positive mast cells (arrowheads) were abundant in the conjunctiva and the corneal stroma of IL33tg mice. (d) The conjunctiva. Bars, 100 µm. (e) The cornea. Bars, 100 µm. Panels are representative of at least three mice and two independent experiments.

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