Table 1 Mean morphometric and metaphyseal bone structure data among lines at baseline (week 0, pooled by treatment), and mean diaphyseal cortical morphological indices at the end of the experiment (week 6). Data presented as means (SEM). Superscripts denote significant differences in means (p < 0.05) between a given group and: CLine C, LS1Line 1, LS2Line 2.

From: Cortical and trabecular morphology is altered in the limb bones of mice artificially selected for faster skeletal growth

Ā 

Line C

Line 1

Line 2

Morphometric Data

Body mass (g)

35.39 (1.07)LS1

39.57 (0.75)C,LS2

36.42 (0.81)LS1

Tibia length (mm)

18.38 (0.14)LS1,LS2

21.26 (0.12)C

21.17 (0.19)C

Baseline Cortical Morphology – Proximal Tibia

TMD (mgHA/cm3)

864.2 (10.8)LS1

810.97 (9.34)LS2,C

860.2 (7.4)LS1

Ct.Th (mm)

0.209 (0.003)LS1

0.171 (0.005)LS2,C

0.209 (0.005)LS1

Ct.Ar (mm2)

1.329 (0.028)LS1,LS2

1.167 (0.033)LS2,C

1.456 (0.036)LS1,C

Imax (mm4)

0.619 (0.023)LS2

0.639 (0.041)LS2

0.807 (0.039)LS1,C

Imin (mm4)

0.482 (0.023)LS2

0.474 (0.03)LS2

0.618 (0.03)LS1,C

J (mm4)

1.101 (0.044)LS2

1.113 (0.072)LS2

1.425 (0.066)LS1,C

Baseline Trabecular Morphology – Proximal Tibia

TV (mm3)

2.039 (0.071)LS1,LS2

2.443 (0.130)C

2.68 (0.087)C

BV (mm3)

0.785 (0.037)LS1,LS2

0.560 (0.047)C

0.535 (0.038)C

BV/TV (%)

38.9 (2.1)LS1, LS2

23.2 (1.9)C

20.2 (1.4)C

Tb.N (1/mm)

5.28 (0.25)LS1,LS2

4.15 (0.26)LS2, C

2.42 (0.13)LS1,C

Tb.Th (mm)

0.085 (0.002)LS1,LS2

0.072 (0.001)C

0.074 (0.001)C

Tb.Sp (mm)

0.186 (0.011)LS2

0.243 (0.020)LS2

0.454 (0.024)LS1,C

6-week Postoperative Cortical Morphology – Distal Tibia

Ct.Ar (mm2)

0.819 (0.023)

0.861 (0.025)

0.8 (0.025)

Ct.Th (mm)

0.231 (0.005)

0.244 (0.008)

0.234 (0.007)

Canal Thickness (mm)

0.019 (0.006)

0.013 (0.002)

0.012 (0.001)

Porosity (%)

0.605 (0.078)

0.608 (0.101)

0.514 (0.073)

Zp (mm3)

0.283 (0.015)

0.293 (0.012)

0.275 (0.012)

Canal Longit Angle (°)

33.8 (1.7)LS1

40.7 (1.7)LS2, C

31.9 (1.3)LS1

Canal Radial Angle (°)

40.8 (1.9)

40.3 (1.6)

40.6 (2.7)