Table 3 Impact of SNPs and haplotypes on diastolic blood pressure.

From: A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling

 

Genotype or haplotype allele

Set

Count

Median (IQR); Mean ± SD - SBP (mm Hg)

P

Ref.

Baseline

Ref.

Baseline

Ref.

Baseline

SNP

 rs2070325

GG

GA/AA

All

46

394

70 (60–80); 73.59 ± 14.78

80 (70–85); 76.99 ± 11.54

0.0259*

 rs11699009

TT

TC/CC

All

54

379

70 (60–90); 75.46 ± 14.99

80 (70–85); 76.79 ± 11.53

0.2772

haplotype

 LAV

LAV homo

LAV carriers/other

All

41

377

70 (60–80); 73.54 ± 14.76

80 (70–85); 76.9 ± 11.67

0.0386*

 WT

WT homo

WT carriers/other

All

149

269

80 (70–80); 76.17 ± 11.77

80 (70–85); 76.8 ± 12.19

0.5652

 RV

RV carriers

other

All

34

384

70 (76–90); 81.47 ± 12.22

80 (70–80); 76.14 ± 11.93

0.0132*

   

On therapy

12

154

90 (80–100); 89.17 ± 9.25

80 (70–80); 76.71 ± 11.27

0.0007*

   

No therapy

22

230

80 (70–88.75); 77.27 ± 11.72

80 (70–80); 75.76 ± 12.37

0.5102

  1. SNP/Haplotype = SNP or haplotype allele; Ref. = reference, effect genotype or haplotype allele; Baseline = baseline genotype or haplotype; set = subset of the cohort analyzed; Count = genotypes or alleles count; Median (IQR); Mean ± SD = median (25th, 75th percentiles) and mean ± standard deviation diastolic blood pressure by genotype or allele; p = p-value from the Wilcoxon rank sum test. *p-value < 0.05.
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