Table 4 Impact of SNPs and haplotypes on systolic blood pressure.

From: A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling

 

Genotype or haplotype allele

Set

Count

Median (IQR); Mean ± SD - SBP (mm Hg)

P

Ref.

Baseline

Ref.

Baseline

Ref.

Baseline

SNP

rs2070325

GG

GA/AA

All

46

394

120 (110–140); 124.57 ± 15.73

130 (120–140); 128.9 ± 15.20

0.0993

rs11699009

TT

TC/CC

All

54

379

130 (110–140); 126.76 ± 17.70

130 (120–140); 128.94 ± 15.12

0.5825

haplotype

LAV

LAV homo

LAV carriers/other

All

41

377

130 (110–140); 124.88 ± 15.83

130 (120–140); 128.79 ± 15.30

0.1906

WT

WT homo

WT carriers/other

All

149

269

130 (120–140); 127.89 ± 14.98

130 (120–140); 128.69 ± 15.61

0.4990

RV

RV carriers

other

All

34

384

130 (120–150); 133.38 ± 18.82

130 (120–140); 127.96 ± 14.98

0.0670

   

On therapy

12

154

150 (137–150); 146.25 ± 15.54

130 (120–140); 130.68 ± 15.67

0.0015*

   

No therapy

22

230

125 (120–138); 126.36 ± 16.85

130 (116–140); 126.14 ± 14.25

0.9182

  1. SNP/Allele = SNP or haplotype allele; Ref. = reference, effect genotype or haplotype allele; Baseline = baseline genotype or haplotype; set = subset of the cohort analyzed; Count = genotypes or alleles count; Median (IQR); Mean ± SD = median (25th and 75th percentiles) and mean ± standard deviation systolic blood pressure by genotype or allele; p = p-value from the Wilcoxon rank sum test. *p-value < 0.05.
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