Figure 2 | Scientific Reports

Figure 2

From: Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed

Figure 2

HRZE treatment perturbs the taxonomic structure of the microbiome. (a) NMDS ordination of HRZE treated subjects (treatment, purple) or LTBI controls (blue) based on 16S rDNA sequencing (b) Family taxonomic distribution of the intestinal microbiota from subjects with LTBI and subjects with TB on treatment. (c) Heatmap of the top 50 most abundant taxa generated with DESeq2 showing unsupervised clustering of TB cases on treatment vs. LTBI controls. Age and sex are also shown but were not accounted for the in DESeq model. Genus and species names are based on OTU identification (Supplementary Table 2) and therefore names may be redundant, but represent different 16S-based OTUs. (d) Taxonomic abundance profiling comparing treatment vs LTBI participants using LeFSe to determine differentially abundant Genera. Box and whisker plots of differentially abundant genera are shown based on the DESeq normalized data. Plots show the first and third quartiles of the abundance data, the line represents the median, and the whiskers show 1.5 times the value of the interquartile range.

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