Figure 3

Taxonomic and biochemical microbiomic perturbation induced by HRZE. (a) NMDS ordination plot on metagenomic taxonomy data demonstrating microbiomic differences between healthy individuals and subjects on HRZE treatment. For this comparison, the healthy group consists of LTBI and Mtb uninfected subjects. (b) Comparative abundance plots between healthy Haitian individuals and cases on HRZE treatment showing the most abundant species. (c) Unsupervised hierarchical clustering of significantly altered taxa from species-level metagenomic data. (d) Abundance of significantly different KEGG modules between healthy volunteers and cases on treatment.