Table 1 Patient populations analyzed in this study by 16S rDNA sequencing. Data are divided into study groups described in the text. The number of subjects, average age, gender distribution, time on HRZE treatment or time since treatment, average number of 16S reads and subsequent OTUs, and Shannon diversity index are shown, if applicable. Mtb-uninfected controls are IGRA−, people with LTBI are IGRA+ , and are the appropriate comparator group for individuals with active TB disease. The LTBI group was divided based on the comparisons being made to Treatment and Cured groups, matching for age (see methods).
Group | Number of subjects | Average Age (range) | % female | Time on TB treatment | Time since TB treatment | Average number of 16S reads per patient (range) | Average number of OTUs per subject (range) | Shannon Diversity |
|---|---|---|---|---|---|---|---|---|
Mtb uninfected | 50 | 33 (19–59) | 62 | N/A | N/A | 35951 (690–116638) | 230 (19–473) | 3.412 |
LTBI (treatment control) | 25 | 26 (17–32) | 52 | N/A | N/A | 41038 (4713–118110) | 229 (47–470) | 3.341 |
LTBI (cured control) | 26 | 25 (17–31) | 46 | N/A | N/A | 40678 (5788–111151) | 243 (47–477) | 3.74 |
Treatment | 19 | 20 (13–32) | 54 | 3.4 months (13–258 days) | N/A | 38489 (4360–140543) | 150 (57–118) | 3.218 |
Cured | 19 | 23 (17–27) | 35 | 6 months | 424 days (34–1202 days) | 19283 (4712–118180) | 239 (133–356) | 3.74 |
